I thought I would chime in on this thread. Sounds like tire wear can point at a number of things. Seems like the trailer shops have a good idea of the cause based on wear.
My tires were both wearing on the outer edges rather than down the middle. I took it in and had the bearings serviced and the axle checked. They inform me that the tires were underinflated causing the wear.
So since my tires were cracked and worn funny, I ordered two Goodyear Marathons from Sam's club. Sams would not take my trailer in the shop, so I either had to bring in the wheels or take it to a tire shop. The local shop had no issues doing the swap.
When I picked up the trailer, I asked them, "I want to try to avoid this again, what pressure should I run these at to avoid unusual wear" He said that trailer tires like this should be run at full pressure. Or just slightly less than the max load/pressure rating on the tire.
Since the tires were a bit squashed standing there, I asked what they were at right now, He said 50lbs. I almost called Bull$#@, but towed it home. I got it in the driveway and tested the tires to find they were both at about 38lbs. I took them right up to 49lbs and it has been towing nicely.
Good luck!