I agree with the comments timeman mentioned. Going from Southbend to ATL, you will probably experience plenty of nice size hills. Make sure your transmission fluid is good in your Murano and not due for a change. I pull my Speedster 150 with a 2WD 4Runner with the V8 and towing package, meaning it comes with a transmission cooler. It pulls that boat great, although I really don't have to pull it often as the boat stays in a boat house. My dad has a highlander and I have pulled my boat with it with no problem at all. There again, I have not gone long distance like you. I think that it could be done, but I would not be in any hurry if I were you. If you have another option, like a pickup or little larger SUV, I would go that route, if not, it is what it is. Good luck.